Genome Biology

Biology for the post-genomic era

Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.

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Louisa Flintoft PhD, Genome Biology

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Articles

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THS-Seq

A transposome hypersensitive sites sequencing assay enables highly sensitive characterization of chromatin accessibility

Genome Biology 2016, 17:20
lncRNA analysis across mammals

An analysis of lncRNAs across mammals indicates these RNAs are a mixture of multiple functional classes with distinct biological roles

Genome Biology 2016, 17:19
Epigenetics and cell differentiation

A new study shows how a single cytokine regulates hematopoietic lineage choice by activating a pathway, which causes dendritic-cell-specific DNA demethylation

Genome Biology 2016, 17:18
Proteome diversification by Alu

A new study examines the input of Alu transposons into human genes

Genome Biology 2016, 17:17
Variability of lncRNAs

Long non-coding RNAs display higher natural expression variability than protein-coding genes in healthy humans

Genome Biology 2016, 17:14
Alu exons and human proteins

This article suggests that Alu elements have contributed to the acquisition of novel protein sequences during primate and human evolution

Genome Biology 2016, 17:15
RNA-seq analysis methods

A comprehensive review of RNA-seq data analysis from experimental design, through read mapping and quantification, to visualization and functional analysis

Genome Biology 2016, 17:13
Cancer super-enhancer methylation

Whole genome bisulfite sequencing in human cancers shows specific aberrant DNA methylation patterns at super-enhancers

Genome Biology 2016, 17:11
Finding mutations in cfDNA

Sequencing of cfDNA of prostate cancer patients identifies a number of androgen receptor mutations with clinical relevance

Genome Biology 2016, 17:10
Genetics of mate choice

This study examines the drivers of mate choice, and finds that genes contributing to height affect individual preferences for mate’s height

Genome Biology 2016, 16:269
Predicting pathogenic mutations

This article describes an approach to indicate intolerant regions in functionally distinct portions of genes: exons and protein domains

Genome Biology 2016, 17:9
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