National Toxicology Program

CASRN: 79-94-7

Formula: C15-H12-Br4-O2

Synonyms/Common Names:

• PHENOL, 4,4'-(1-METHYLETHYLIDENE)BIS(2,6-DIBROMO (9CI)
• TBBPA

Known Uses:

Flame retardant for plastics, paper, and textiles.

Nomination Background

Short-Term Toxicity

• 13 weeks (Gavage)  (C20033)  Assigned 
  • Toxicogenomics
  • Rats: Wistar Han
  • Dose: 0, 23, 250, or 1000 mg/kg.
• 13 weeks (Gavage)  (C20320)  Completed 
  • Rats: F344/NTac; Mice: B6C3F1/N
  • Dose: R&M: 0, 10, 50, 100, 500, OR 1000 MG/KG; R: 20/SEX/DOSE; M: 10/SEX/DOSE.

Long-Term Carcinogenicity

• 2 years (Gavage)  (C20320)  Report Draft 
  • TR-587
    Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice (Gavage Studies)
  • Rats: Wistar Han; Mice: B6C3F1/N
  • Dose: R&M: 0, 250, 500, OR 1000 MG/KG; 50/SEX/SPECIES/DOSE.

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0897)  Completed 
  • Citation: Chemical Disposition in Mammals. I. Glenn Sipes; A. N. Solyom. Dept of Pharmocology, Collegeg of Medicine, University of Arizona. October 1, 2004 - December 31, 2004. Absorption, Distribution, Metabolism and Excretion of Tetrabromobisphenol A (TBBPA) in Male F-344 Rats.
  • Male Rats: F344/N
  • Dose: 2,20, or 200 mg/kg; 20 mg/kg, 50 uCi/kg, 1 ml/kg.

Genetic Toxicology

• Micronucleus  (A13260)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (968573)  Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (G20033)  Completed 

Toxicogenomics

• Microarray Analysis (Gavage) Selected (T20033)  
  • Microarray and RT-PCR
  • Rats: Wistar Han