A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Cell, Volume 146, Issue 3,
Pages 353-358,
Publication Date 28 July 2011
Copyright © 2011 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.cell.2011.07.014
Leonardo Salmena
Laura Poliseno
Yvonne Tay
Lev Kats
Pier Paolo Pandolfi
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Corresponding author
Present address: Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
Summary
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs “talk” to each other using microRNA response elements (MREs) as letters of a new language. We propose that this “competing endogenous RNA” (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.